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jakbiochem@ru.ac.bd

http://www.ru.ac.bd/biochemistry/details/?sid=22300560


Dr. Jahan Ara Khanam
PROFESSOR
Biochemistry & Molecular Biology


Education Summary  
PhD (India)

Research Interest  
Oncomedicine and Anticancer Drug Design
Level Institution Year
Doctoral
(Doctor of Philosophy)
Department of Chemistry, Jadavpur University, Calcatta-700032, India 1998
Masters
(Master of Science (Biochemistry and Molecular Biology))
Rajshahi University 1981
Bachelor/Honors
(Bachelor of Science (Applied Chemistry and Chemical technology))
Rajshahi University 1980

Experience in Rajshahi University

Duration Organization/Institute Position
2002-11-10 to Biochemistry & Molecular Biology PROFESSOR
1997-10-15 to 2002-11-14 Biochemistry & Molecular Biology Associate Professor
1987-10-15 to 1997-10-14 Biochemistry & Molecular Biology Assistant Professor
1984-10-15 to 1987-10-14 Biochemistry & Molecular Biology Lecturer

Experience in other Organization/Institute

Not Available

Journal

1. . Plabon Kumar Das, Suja Pillai, MdAbdurRakib, JahanAraKhanam,VinodGopalan, Alfred KY Lam, Farhadul Islam "Plasticity of cancer stem cell: origin and role in disease progression and therapy resistance." Stem cell reviews and reports; 1-16

Published: September 2021
2. . Mst Ayesha Siddika, Plabon K Das, Saharia Y Asha, SuraiyaAktar, Abu Rahyan M Tareq, Ayesha Siddika, MdAbdurRakib, Farhadul Islam, JahanAraKhanam. "Antiproliferative Activity and Apoptotic Efficiency of Syzygiumcumini Bark Methanolic Extract against EAC Cells In Vivo." Anti-cancer agents in medicinal chemistry; (7)/2020

Published: June 2020
3. SuraiyaAktar, Plabon Kumar Das, SahariaYeasmin Asha, Mst Ayesha Siddika, Farhadul Islam, JahanAraKhanam, MdAbdurRakib "Moringaoleifera leaves methanolic extract inhibits angiotensin converting enzyme activity in vitro which ameliorates hypertension." J AdvBiotechnolExpTher.; 2(2): 73-77

Published: April 2020
4. Plabon Kumar Das, Mst Ayesha Siddika, SahariaYeasmin Asha, SuraiyaAktar, MdAbdurRakib, JahanAraKhanam, Suja Pillai, Farhadul Islam. "MicroRNAs, a promising target for breast cancer stem cells." Molecular diagnosis & therapy; 24 (1): 69-83

Published: January 2020
5. King-Yin Lam MahbubaKhatun, Farhadul Islam*, VinodGopalan, Md. Motiar Rahman, Natasha Zuberi, LaboniKhatun, Md. AbdurRakiba, Md. Azizul Islam, JahanAraKhanam. "2', 4'-dihydroxy-3, 4-methylenedioxychalcone Activate Mitochondrial Apoptosis of Ehrlich Ascites Carcinoma Cells." Current Drug Therapy; 15 (4), 337-350

Published: December 2019
6. . Plabon K Das, TasnimZahan, AbdurRakib, Jahan A Khanam, Suja Pillai, Farhadul Islam. "Natural compounds targeting cancer stem cells: a promising resource for chemotherapy." Anticancer Agents in Medicinal Chemistry;19 (15): 1796-1808

Published: December 2019
7. . Plabon K Das, Md A Rakib, Jahan A Khanam, Suja Pillai, Farhadul Islam. "Novel therapeutics against breast cancer stem cells by targeting surface markers and signaling pathways" Current stem cell research & therapy; 14 (8): 669-682

Published: December 2019
8. . RuksanaYesmin, Plabon Kumar Das, HazratBelal, SuraiyaAktar, Mst Ayesha, MdAbdurRakib, Farhadul Islam, JahanAraKhanam. "In vitro antioxidant and antidiabetic assessment of extracts from the bark of micheliachampaca, a medicinal plant in Bangladesh." World Journal of Pharmaceutical Research; 8 (9): 1505-1526.

Published: November 2019
9. . Plabon Kumar Das, Mst Ayesha Siddika, SahariaYeasmin Asha, SuraiyaAktar, Farhadul Islam, JahanAraKhanam, MdAbdurRakib. "Investigation of phytochemicals and antioxidant activities in the leaves methanolic extract from Moringaoleifera plants grown in Bangladesh" Journal of Pharmacognosy and Phytochemistry 8 (4), 2502-2508

Published: August 2019
10. Islam F, Khanam JA, Khatun M, Zuberi N, KhatunL, Kabir SR, Reza MA, Ali M,Rabbi MA, Gopalan V, LamAK. "A p-Menth-1-ene-4,7-diol (EC-1) from EucalyptuscamaldulensisDhnh. Triggers Apoptosis and Cell Cycle Changes in Ehrlich Ascites Carcinoma Cells. Islam F, Khanam JA, Khatun M" PhytotherapyResearch; 29 (4), 573-581

Published: December 2015
11. Islam F, Ghosh S, Khanam JA. "Antiproliferative and hepatoprotectiveactivityof metabolites from Corynebacteriumxerosis against Ehrlich Ascites Carcinomacells. I" Asian Pacific Journal Tropical Biomedicine ;4:S284-92.

Published: November 2014
12. Farhadul Islam, M. M. Ali and J.A.Khanam "HepatoprotectiveEffect of Acetone Semicarbazone (ASC) on Ehrlich Ascites Carcinoma (EAC) induced carcinogenesis in experimental mice." Asian Pacific Journal of Tropical Biomedicin,2013;3(2): 105-110.

Published: September 2013
13. Farhadul Islam, Hasinakhatun, Mahbubakhatun, Shaikh MohummadMohsin Ali and JahanAraKhanam. "Growth inhibition and apoptosis of Ehrlich ascites carcinoma cells by methanol extract of Eucalyptus camaldulensis." Pharmaceutical biology, 2013; 1-10.

Published: February 2013
14. N Yusuf, M Ahmed Ali, M F Islam and J.A.Khanam "Screening of Cervical Cancer by VIA among women in Rajshahi Medical College Hospital." Asian Pacific Journal of Tropical Diseases 2(1): 70-72

Published: December 2012
15. . M. H. Morshed, M. F. Islam, M. A. Yousuf, G.M.G. Hossain, J. A. Khanam and M.A. Salam "Synthesis and antimicrobial screening of three triazole derivatives. M. H. Morshed, M." Dhaka Univ. J. Pharm. Sci. 10 (1): 43-47

Published: September 2011
16. . RasidaPerveen. Farhadul Islam, JahanAraKhanamand TanzimaYeasmin. "Preventive effect of Ethanol Extract of AlpiniacalcarataRosc on Ehrlich’s ascitic carcinoma cell induced malignant ascites in mice. RasidaPerveen" Asian Pacific Journal of Tropical Medicine; 5(2):121-125

Published: August 2011
17. . Farhadul Islam, HasinaKhatun, Soby Ghosh, M.M. Ali and J. A. Khanam "Bioassay of Eucalyptus Extracts for Anticancer Activity against Ehrlich Ascites Carcinoma (EAC) Cells in Swiss Albino Mice." Asian Pacific Journal of Tropical Biomedicin2

Published: June 2011
18. . N. Yusuf, M. F. Islam, H. Akhter, J. A. Khanam "Early Detection of Cervical Intraepithelial Lesions by Simple Visual Inspection after Acetic Acid among Women in Rajshahi Medical College Hospital" Anatolian Journal of Obstetrics & Gynecology; 2(1): 70- 72.

Published: March 2011
19. . J. A. Khanam, M.F. Islam, M. Jesmin and M. M. Ali "Antineoplastic activity of acetone semicarbazone (ASC) against Ehrlich Ascites Carcinoma (EAC) bearing mice." J.Natn.Sci.Foundation Sri Lanka 38 (4):225- 231

Published: July 2010
20. . M.Jesmin, M. M. Ali and J. A. Khanam. "Antineoplastic activity of some schiff bases derived from benzoin salicylaldehyde, aminphenol and 2,4-dinitrophenol hydrazine." Thai J of Phar. Sci. 2010; 34:20-31.

Published: May 2010
21. M. H. Morshed, M. F. Islam , M. A Yousuf G.M.G. Hossain ,M. R. Habib and J.A.Khanam. "Cytotoxic Nature of Three Triazole Derivatives," Journal of Engineering Science (1) 121-125.

Published: February 2010
22. M.M.Ali, M.Jesmin, S.M.A.Sahan, J.A.Khanam,M.F.Islamand M. N. Islam. "Pesticidal activity of some schiff bases derived from benzoin salicylaldehyde, aminphenol and 2,4-dinitrophenol hydrazine." J. Sc. Research 1(3), 641-646

Published: December 2009
23. M. Jesmin, M.M. Ali, M. R. Rahman,M. R. Habib and J. A. Khanam "Mercury(II) Cystine complex as antineoplastic agent." Med. J. Isl. W. Acad. Sci.17:2, 81-86

Published: February 2009
24. .M.M.Ali, M.Jesmin, S.M.A.Sahan, J.A.Khanam,M.F.Islamand M. N. Islam. "Pesticidal activity of some schiff bases derived from benzoin salicylaldehyde, aminphenol and 2,4-dinitrophenol hydrazine.M.M.Ali, M.Jesmin," .M.M.Ali, M.Jesmin, S.M.A.Sahan, J.A.Khanam,M.F.Islamand M. N. Islam.

Published: January 2009
25. M. Jesmin M.M. Ali.M.N.IslamM.N.Islam,S.M.S.Shariarand J. A. Khanam. "Pesticidal Activity of Schiff Base Complexes Derived from some Divalent Metal Acetates, Glycine and Salicylaldehyde." J. Sci. Foundation 6(2), 49-56

Published: November 2008
26. .M.Ali,M.Jesmin,M.K.Sarker,M.S. Salahuddin, M.R. Habib and J. A. Khanam "Antineoplastic Activity of N- Salicylideneglycinato-di-aqua Ni (II) Complex Against Ehrlich Ascites Carcinoma (EAC) Cells inMiceM.M.Ali,M.Jesmin,M.K.Sarker,M.S." Int. J. BiolChen. Sci. 2(3); 292-98

Published: October 2008
27. M. Jesmin M.M. Ali, M.S. Salahuddin, M.R. Habib, M.R. Habiob&J. A. Khanam "Antimicrobial Activity of Some Schiff Base Derived from Benozin. Salicylaldihyde, Aminophenol and 2.4 Dinitrophenyl Hydrazine" Mycobiology 36(I),70-73

Published: September 2008
28. J. A. Khanam. M.S.Salahuddin, M.R. Habib, M. R. Islam, M. Jesmin, M.K. Sarker&M. M. Ali "Antineoplastic Activity of Bis-TyrosinediawuaNi (II) Against Ehrlich Against Ehrlich Ascites Carcinoma" Dhaka University J. Pharm. Sci. 7 (I),33-37

Published: August 2008
29. .M.R.Islam,S.M.R.Islam, A.S.M Noman. J. A. Khanam, M.M. Ali, S. Alam and M.W.Lee. "Biological Screening of a novel nickel (II) tyrosinecomplex." Mycobiology35(I): 25-27

Published: June 2007
30. . M. Jesmin, M.M. Ali, A.K. Biswas, M.R. Habib &J. A. Khanam. "Antineoplastic Activity of Nickel (II) Cystine Complex Against Ehrlich Ascities Carcinoma in Swiss Albino Mice." Med. J. Isl. World Acad. Sci. 16(3)135- 142

Published: May 2007
31. J. A. Khanam. M. F. Begum. J.Ara, M. Jesmin, M.A. Taher& M.M. Ali "Toxicity of Some Metal Cystine Complexes Against Confused Flour Beetle, Tribolium Castanceum (Coleoptera: Tenebrionidae)" Bang. J. Life. Sci, 19(1) 115-119

Published: March 2007
32. . J. A. Khanam. M. F. Begum. J.Ara, M. Jesmin, M.A. Taher& M.M. Ali "Antimicrobial Activity of Metal cystineComplexes." Dhaka University J. Pharm. Sci. 5 (1-2):29- 32

Published: May 2006
33. . A. Y. K. M. MasudRana, J. A. Khanam& M. Asad-ud-Daula. "Antineoplastic Screening of Some Medicinal Plants Against Ehrlich Ascities Carcinoma in Mice." J. Med Sci. 4 (2),; 142-145

Published: April 2004
34. , J. A. Khanam& A. Y. K. M.MasudRana "Antibacterial and Antifungal Activity of 2- oxo- Benzylidine (3-oxo-Aniline) Cu (II)- ethylidine" J. Med. Sci, 4 (2); 124- 127

Published: March 2004
35. J. A. Khanam, A. Y. K. M. MasudRana, M. Akhtaruzzaman& M. Shajajahan. "In Vitro Antibacterial Activity of 2,2-Diamino-1- AzavinylAminoamide." J. Med. Scic. 2 (4) PP (198-201)

Published: February 2002
36. , A. Y. K. M. MasudRana andJ. A. Khanam. "Aristolochiaindica. Whole plant Extract as an Antineoplastic Agent," J. Med. Sci. 2 (4) pp (202-205)

Published: February 2002
37. J. A.Khanam&A.Y. K. M. MasudRana. "Antineoplastic Activity of Chloroacetohydroxamic Acid in Combination with Bleomycin Against Ehrlich Ascites Carcinoma (EAC) in Mice." The Sciences, 1 (5)PP.288-291

Published: January 2001
38. . J. A. Khanam, S. Ray & A. Y. K.M. MasudRana. "Antineoplastic Activity of Cyanohydroxamic Acid (Sodium Salt) Against Ehrlich Ascites Carcinoma in Mice." . J. A. Khanam, S. Ray & A. Y. K.M. MasudRana.

Published: January 2001
39. J.A.Khanam. "Antitumour and Anti-inflammatory Actvities of Hydroxmic Acids and Hydoxyurea." Saudi Pharm. J., 8 (I) PP.39-42

Published: December 2000
40. . M.A. A. Rahman, M. T. M. Z. Azam, J. A. Khanam,& M. A. Gafur. "In vivo Cytostatic Activity of a Flavonoid Isolated from ClerodendumIndicum on Ehrlich Ascite Carcinoma (EAC) Cells Injected in Mice." J. Asiat. Soc. Bangladesh, 26(2) PP. 289-291

Published: March 2000
41. . J. A. Khanam, A. K. Azad, M. S. Zaman& M A Mottaleb "Analysis of Ground Water Samples Collected from Hand and Deep Tube Wells of Godagari Region in Western Part of Bangladesh." The Rajshahi University Studies Part (B) (in press)

Published: March 2000
42. J. A. Khanam. "Antineoplastic Activity of Chloroacctohydroxamic Acid in Combination with Ultrasound." Bang. J. Biochem., 5, PP25-34.

Published: January 1999
43. J. A. Khanam, S. P. Bag, B. Sur & P. Sur. "Comparative Study of Antineoplastic Activity of Some Aliphatic and Aromatic Hydroxamic Acids Against Earlich Ascites Carcinoma (EAC)in Mice. J. A. Khanam, S. P. Bag, B. Sur & P. Sur. Comparative Study of Antineoplastic Activity of Some Aliphatic and Aro" Med. J. Isl. Acad. Sci., 11(2) PP 57-64

Published: February 1998
44. J. A. Khanam, & M. K. Hasan. "Physico Chemical and Bacteriological Analysis of a Few Surface and Under Ground Water Samples from Nawabganj and Rajsahi Metropolis A Case Study." J. Bio-Sci., 6, PP 155- 159

Published: January 1998
45. J.A. Khanam, S. P. Bag, B. Sur & P. Sur. "Antineoplastic Activity of Copper- Benzohydroxamic Acid Complex Against Ehrlich Ascites Carcinoma (EAC) in Mice" Indian J. Pharmacology 29, PP 157-161

Published: May 1997
46. P. Sur, S. P. Bag, B. Sur & J. A. Khanam "Chloroaceto Hydroxamic Acid as Antitumor Agent Against Ehrlich Ascites Carcinoma in Mice" Neoplasma 44 (3). PP 197-201

Published: January 1997
47. J. A. Khanam, A. K. Azad, M. R Haque & M.S. Zaman. "Seasonal Variation of the Pollution Levels of Surface Water of Godagri Region in Western Part of Bangladesh" The Rajshahi University Studies. (Part-B), 25

Published: January 1997
48. N. Absar, M. Shahjahan, J. A. Khanam, M. Quaisuddin, M Hassan & M. K. Rahman. "Studies on the Boichemical and Nutritional Aspects of the Different Varieties of Mangoes of Rajshahi Region" The Rajshahi University Studies. (Part-B) 16, PP 209-219

Published: January 1988

Basic Biochemistry, Metabolism , Molecular Biology , Oncology ,

Description Not Provided

Running

Research Work in M. Sc Courses:

1.  Title of thesis: Antineoplastic and Antimicrobial activity of Cyanobroxamic acid, some medicinal plant extract and Monocilium metabolites.

Name of Research Scholar- Santunu roy Examination-1996

2.  Title of thesis: Antineoplastic activity of some medicinal plants. Name of Research Scholar- Md. Masud Rana

Examination-1997

3.  Title of thesis: Synthesis and Characterization of Semicarbazone and Study of its Antifumgal and Antibacterial Activities.

Name of Research Scholar- Md. Akhtar-Uzzaman Examination-1998

4.  Title of thesis: Antineoplastic and Antifungal and Antibacterial activities of Copper (II) complex of Ethylene diamine with Schiff-base.

Name of Research Scholar- Md. Asad-Ud-Daula Examination-1999

5.  Title of thesis: Antineoplastic and Antifungal and Antibacterial activities of Nikel (II) Tyrosine complex.

Name of Research Scholar- Md. Rafiqul Islam Examination-2000

6.    Title of thesis: Insecticidal and Antifungal and Antibacterial activity of Nikel (II) Cystein complex.

Name of Research Scholar- Sultana Yeasmin (Lata). Examination-2001

7.  Title of thesis: Antineoplastic and Antibacterial activities of N,N Dihydroxy Benzyl Aniline (DBA) and Dimethyl Glyoxime (DMG)

Name of Research Scholar- Md. Mostafizur Rahman Examination-2002.

8.  Title of thesis: Antineoplastic and Antibacterial activities of N-(1-phenyl -2 Hydroxy-2 phenyl Ethylinedine)-2', 4'- Dinitrophenyl Hydrazone (PDH).

Name of Research Scholar- Md. Sultan Salauddin Examination-2004


9.  Antineoplastic and Insecticidal activity of N-( 2hydroxy benzyldiene) 2' hydroxyl phenyl- imine aqua Nikel (II) complex [Ni 9H2O) HHP].

Name of Research Scholar- Ismat Ara Hossain Examination-2005

10.   Antineoplastic, Antibacterial and Toxicological Studies of Acetone Semicarbazone (ASC). Name of Research Scholar- Md. Farhadul Islam

Examination-2006

111.             Antineoplastic activity of medicinal plants.

Name of Research Scholar- Hasina Khatun

 Examination-2008

112.             Antineoplastic activity of Metabolites Extracted from Isolated Soil Bacteria.

Name of Research Scholar- Soby Ghosh

Examination-2009

113.            Antiprpliferative Activity of Benzophenome Thio-micarbazone Against EAC cells in Mice Model

Name of Research Scholar- Rubaya Pervin  

114.           Examination- 2012

115.            In Vivo Antineoplastic Activity of Chalcones

Name of Research Scholar- Mahbuba Khatun  

Examination- 2013

116.             Antineoplastic Activity of Michelia Champaca Seed Against EAC cell line in vivo.

Name of Research Scholar- Laboni Khatun  

Examination- 2014

117.             Antioxidant and Antiproliferative Activity of Methanolic Extract of Phyllunthus acidus fruit

Name of Research Scholar- Md Shohidul Islam  

Examination- 2015

118.            Phytochemical Investigations, Antioxidant and antineoplastic activity of Michelia Champaca Bark

 Name of Research Scholar- Roksana Yeasmin  

Examination- 2016

119.            Antiproliferative activity of Salicylaldehyde thiosemicarbazone Against EAC cells both in vitro and in vivo

Name of Research Scholar- Suraya Akhter  

Examination- 2017

220.             Study of Antiproliferative and Apoptotic Properties of Syzygium Cumini Bark Methanolic Extracts Against EAC cells

Name of Research Scholar- Laboni Khatun  

Examination- 2019

 

Research Work in PhD Courses:


1.  Title of thesis: Cervical cancer Screening by Simple Visual Inspection after Acetic acid. Name of Reseach Scholar-Dr. Nahid Yusuf

Awarded-2015

2. Title of thesis:  Assessment of Spinosad for control of the flat  Grain Beetle Cryptolestes Pussilus( SCHON) ( CHOLEOPTERA : CUCUZEDAE)

Name of research scholar: Zahida Begum. Session  2019-20

3.Title of thesis: Anticancer Activity of {Cu( tet am)No3} complex against EAC cells in   mitochondrial  P53/jnk path ways  and its effect on RET-Hb.  Name of scholar  Mira Akthar.  Session 2021-22

4. Title of thesis: Study of Grewia AristcaL. Extract on EAC cell growth inhibitory effect , immunomodulatory and and antihypertensive activity in mice model. Name of research scholar: Wakif Khan. Session: 2022=23

5. Title of thesis:Bioactive Metabolites Isolated from Microorganism and study of its  Anticancer activity. Session 202




Research Projects/Funding Received



Title of the Projects

Funding Year/Funding NO

Funded by

Role

Remark

Development of Drugs Design in the treatment of cancer

1998-1999

A-2/5/52/B/98-99

Rajshahi University

Principal Investigator

Completed

Development of Anticancer Drugs from medicinal plant extracts

1998-1999

-1/98/292(62)

Ministry of Science & Technology

Bangladesh

Principal Investigator

Completed

Study of Anticancer Activity of some metal complexes

2004-2005

A-105/-5/52/Science/2004-05

Rajshahi University

Principal Investigator

Completed

Study of Antineoplastic and anti-inflammatory Activities of medicinal plant extracts

2007-2008

6(76)UGC/Chem/1027

UGC Bangladesh

Principal Investigator

Completed

Development of Research Lab in a view to Formulate Novel Anticancer Drugs for future

2011-2012

39.009/002.01.00.04/832

Ministry of Science & Technology

Bangladesh

Principal Investigator

Completed

Development of Anticancer Drug Design laboratory in Advanced level in a view to Formulate Novel Anticancer Drugs

2013-2014

10 M-15/2007 part-2/212

Ministry of Education

Bangladesh

Principal Investigator

Completed

Study of Growth inhibitory Effect of EAC cells and Apoptosis Inducing activities of Microbial Extracts

2011-2012

Bangladesh medical Research Council

Principal Investigator

Completed

Anticancer Activity of Chalcons in vivo Against EAC cells

2013-2014

6(75)/UGC/RSP?Bka/(22)/2013/4732

UGC Bangladesh

Principal Investigator

Completed

Antiproliferative Activity of Metabolites Extracted From Isolated Microorganisms of Environment

2014-2015

622-5/52/Research grant/Science/2012

Rajshahi University

UGC

Principal Investigator

Completed

Antiproliferative activity of a Schiff base in vivo and in vitro culture of EAC cells

2017-2018

15/52/RU.Science-09/17-18/70

Rajshahi University

 

Principal Investigator

Completed

Phytochemical profiling, antioxidant activity of Annona Aquamosa L. fruit pulp and its Anticancer efficiency with understanding molecular mechanism in Ehrlich Ascites Carcinoma (EAC) cells in Swiss Albino mice

2019-2020

1182/5/52

Rajshahi University

 

Principal Investigator

Continuing

 

Society Affiliation: Bangladesh Biochemical Society

Scholarship: Awarded SAARC scholarship while Ph. D degree.

Not Available